اثر حفاظتی پپتید غنی از پرولین هیپوتالاموس (PRP-1) روی بیماری آلزایمر ایجاد شده بوسیله بتا آمیلوئید (Aβ25-35) در موش صحرایی

    Background & Aims: Alzheimer’s disease is an irreversible, degenerative, and progressive brain disease that slowly destroys the memory and thinking skills and the ability to carry out the simplest tasks. Proline rich peptide (PRP -1) is produced from neurosecretory cells of hypothalamus that has large spectrum of biological action on immune and nervous system . The aim of this research was to study the protective effect of PRP-1on the model of Alzheimer’s disease induced by β amyloid protein.   Materials & Methods : The present experimental study was carried out on 2 4 adult male Wistar rats weighing 230±30 grams and 3-4 months old. At first, the rats were randomly divided into three groups (normal, Amyloid and Amyloid with PRP-1). In the control group without injection of β amyloid solution and PRP-1, in the amyloid group after injection of β amyloid 3 m Lit and the amyloid with PRP-1 group after injection of β amyloid and treatment with PRP-1 experiments of morphology for reviling of ca2 depended acidic phosphates were performed.   Results: It was observed that a characteristic morphological sign in A β -induced neurodegeneration are the sharp fall in phosphatase activity, a complete lack of neurofibrils response in large pyramidal cells and mosaic extinction of the reaction of neurons in the architectonics of the cerebral cortex cellular layers. The results of studies after the introduction of A β suggests that when PRP-1 positive changes are observed in the structural properties of neurons such as the increase of metabolism, increase of the density of the location of neurons in the fields of the hippocampus, and pyramidal layer of the cortex determines cell survival.   Conclusion : Our studies on the application of PRP-1 have a tendency to show that given the small effect of the pathological manifestations, the favorable conditions for the timely and vigorous treatment of a significant part of cellular changes is reversible.     SOURCE: URMIA MED J 2013: 24(7): 517 ISSN: 1027-3727